Conversion of childhood acute lymphocytic leukemia (L2) with a double t(12;21) to juvenile myelomonocytic leukemia with a novel t(4;11)(p12;q23): A cytogenetic, morphologic, and immunophenotypic study (2024)

Manor, E., Shubinsky, G., Moser, A. M., Gurevitch, D., Chatach, F., Yermiahu, T., & Kapelushnik, J. (2003). Conversion of childhood acute lymphocytic leukemia (L2) with a double t(12;21) to juvenile myelomonocytic leukemia with a novel t(4;11)(p12;q23): A cytogenetic, morphologic, and immunophenotypic study. Cancer Genetics and Cytogenetics, 147(2), 110-114. https://doi.org/10.1016/S0165-4608(03)00200-0

Manor, Esther ; Shubinsky, George ; Moser, Asher M. et al. / Conversion of childhood acute lymphocytic leukemia (L2) with a double t(12;21) to juvenile myelomonocytic leukemia with a novel t(4;11)(p12;q23) : A cytogenetic, morphologic, and immunophenotypic study. In: Cancer Genetics and Cytogenetics. 2003 ; Vol. 147, No. 2. pp. 110-114.

@article{23304f462f5849049a39c0273e32fb4d,

title = "Conversion of childhood acute lymphocytic leukemia (L2) with a double t(12;21) to juvenile myelomonocytic leukemia with a novel t(4;11)(p12;q23): A cytogenetic, morphologic, and immunophenotypic study",

abstract = "Here we describe a cytogenetic and flow-cytometric study of a case in which a conversion of childhood acute lymphocytic leukemia (ALL) into juvenile myelomonocytic leukemia (JMML) occurred. A 3-year-old boy diagnosed CALLA+, pre-B-ALL with double t(12;21) (by fluorescence in situ hybridization analysis), was treated as per the BFM protocol. A cytogenetic analysis performed at 17 months into treatment showed no t(12;21) in bone marrow (BM) cells; however, a novel translocation, namely, t(4;11), involving the p12 locus on chromosome 4 and the MLL gene at 11q23 was detected in monocytes. No cytogenetic abnormalities were found either in Epstein-Barr virus-transformed B cells or in phytohemagglutinin-stimulated T-lymphoid cells. Flow-cytometric analysis demonstrated an asynchronous expression of the antigenic determinants in populations of granulocytic and monocytoid cells: 60% of monocytes expressed low levels of CD14, an unusually high level of CD15, and no CD13 or HLA-DR antigens; 74% of myeloid cells expressed no CD13. Our results indicate that the transformation from B-cell ALL to JMML in this case occurred most probably in the granulocyte-erythroid-macrophage-megakaryocyte progenitor cells without involving the lymphoid cell line. To date, the child is 10 months off therapy and asymptomatic, with t(4;11) in only 3% of the cells.",

author = "Esther Manor and George Shubinsky and Moser, {Asher M.} and Dora Gurevitch and Fanny Chatach and Tikva Yermiahu and Joseph Kapelushnik",

year = "2003",

month = jan,

day = "1",

doi = "10.1016/S0165-4608(03)00200-0",

language = "English",

volume = "147",

pages = "110--114",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "2",

}

Manor, E, Shubinsky, G, Moser, AM, Gurevitch, D, Chatach, F, Yermiahu, T & Kapelushnik, J 2003, 'Conversion of childhood acute lymphocytic leukemia (L2) with a double t(12;21) to juvenile myelomonocytic leukemia with a novel t(4;11)(p12;q23): A cytogenetic, morphologic, and immunophenotypic study', Cancer Genetics and Cytogenetics, vol. 147, no. 2, pp. 110-114. https://doi.org/10.1016/S0165-4608(03)00200-0

Conversion of childhood acute lymphocytic leukemia (L2) with a double t(12;21) to juvenile myelomonocytic leukemia with a novel t(4;11)(p12;q23): A cytogenetic, morphologic, and immunophenotypic study. / Manor, Esther; Shubinsky, George; Moser, Asher M. et al.
In: Cancer Genetics and Cytogenetics, Vol. 147, No. 2, 01.01.2003, p. 110-114.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Conversion of childhood acute lymphocytic leukemia (L2) with a double t(12;21) to juvenile myelomonocytic leukemia with a novel t(4;11)(p12;q23)

T2 - A cytogenetic, morphologic, and immunophenotypic study

AU - Manor, Esther

AU - Shubinsky, George

AU - Moser, Asher M.

AU - Gurevitch, Dora

AU - Chatach, Fanny

AU - Yermiahu, Tikva

AU - Kapelushnik, Joseph

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Here we describe a cytogenetic and flow-cytometric study of a case in which a conversion of childhood acute lymphocytic leukemia (ALL) into juvenile myelomonocytic leukemia (JMML) occurred. A 3-year-old boy diagnosed CALLA+, pre-B-ALL with double t(12;21) (by fluorescence in situ hybridization analysis), was treated as per the BFM protocol. A cytogenetic analysis performed at 17 months into treatment showed no t(12;21) in bone marrow (BM) cells; however, a novel translocation, namely, t(4;11), involving the p12 locus on chromosome 4 and the MLL gene at 11q23 was detected in monocytes. No cytogenetic abnormalities were found either in Epstein-Barr virus-transformed B cells or in phytohemagglutinin-stimulated T-lymphoid cells. Flow-cytometric analysis demonstrated an asynchronous expression of the antigenic determinants in populations of granulocytic and monocytoid cells: 60% of monocytes expressed low levels of CD14, an unusually high level of CD15, and no CD13 or HLA-DR antigens; 74% of myeloid cells expressed no CD13. Our results indicate that the transformation from B-cell ALL to JMML in this case occurred most probably in the granulocyte-erythroid-macrophage-megakaryocyte progenitor cells without involving the lymphoid cell line. To date, the child is 10 months off therapy and asymptomatic, with t(4;11) in only 3% of the cells.

AB - Here we describe a cytogenetic and flow-cytometric study of a case in which a conversion of childhood acute lymphocytic leukemia (ALL) into juvenile myelomonocytic leukemia (JMML) occurred. A 3-year-old boy diagnosed CALLA+, pre-B-ALL with double t(12;21) (by fluorescence in situ hybridization analysis), was treated as per the BFM protocol. A cytogenetic analysis performed at 17 months into treatment showed no t(12;21) in bone marrow (BM) cells; however, a novel translocation, namely, t(4;11), involving the p12 locus on chromosome 4 and the MLL gene at 11q23 was detected in monocytes. No cytogenetic abnormalities were found either in Epstein-Barr virus-transformed B cells or in phytohemagglutinin-stimulated T-lymphoid cells. Flow-cytometric analysis demonstrated an asynchronous expression of the antigenic determinants in populations of granulocytic and monocytoid cells: 60% of monocytes expressed low levels of CD14, an unusually high level of CD15, and no CD13 or HLA-DR antigens; 74% of myeloid cells expressed no CD13. Our results indicate that the transformation from B-cell ALL to JMML in this case occurred most probably in the granulocyte-erythroid-macrophage-megakaryocyte progenitor cells without involving the lymphoid cell line. To date, the child is 10 months off therapy and asymptomatic, with t(4;11) in only 3% of the cells.

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U2 - 10.1016/S0165-4608(03)00200-0

DO - 10.1016/S0165-4608(03)00200-0

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AN - SCOPUS:0242575111

SN - 0165-4608

VL - 147

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JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

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Manor E, Shubinsky G, Moser AM, Gurevitch D, Chatach F, Yermiahu T et al. Conversion of childhood acute lymphocytic leukemia (L2) with a double t(12;21) to juvenile myelomonocytic leukemia with a novel t(4;11)(p12;q23): A cytogenetic, morphologic, and immunophenotypic study. Cancer Genetics and Cytogenetics. 2003 Jan 1;147(2):110-114. doi: 10.1016/S0165-4608(03)00200-0